I had lip filler on my upper lip and around ten days after, these bumbs started appearing. It wasn't my first time having lip filler, but this time a different technique was used. Also there's a spot were it's placed superficial. I visited two dermatologists since then, the first gave me an ointment containing cortisone and antibiotic for a month, which didn't work, and then suggested CO2 laser. The second dermatologist said that CO2 laser was not gonna work and prescribed a tacrolimus 0,1 ointment, twice a day for a month. I'm using it five days now and i've noticed new bumbs, or probably granulomas as they said, have suddenly appeared, despite the fact my lip was unchanged for a long time. Can tacrolimus make my lip condition worst? Have anyone experienced this and resolved it?