Spent the the night in the ER after 4 days of non-stop itching/rashes/hives. I stopped taking Spiro (my dose was 50mg 2x/day) on Saturday. Today is Thursday and I am still miserable from itching all over my body, but mainly palms/hand, feet and torso. I have had occasional flare-ups behind my knees, on my shin and groin area and on and around my ears. Most of the time when an area starts feeling better, I flare up in another spot. My allergic reaction was delayed by weeks. For me it was 3 weeks. ER docs and nurses swear up and down that it's not the Spiro but for me nothing has changed other than taking the medication.